Intermittent Heterochronic Plasma Exchange as a Modality for Delaying Cellular Senescence.

...the above described animal models of heterochronic parabiosis provide convincing evidence that cellular senescence can be modulated by systemic factors that change with age. Blood borne factors present in the systemic milieu inhibit or promote cell genesis. Plasma exchange is a medical procedure which effectively can remove aging plasma and replace it with fluids that will provide an environment conducive to cell rejuvenation (Fig. 2). The choice of replacement fluids will be very important. Plasma from young, healthy individuals would be an obvious choice. *con't..

Dobri D Kiprov 1 Affiliation:

• 1Division of Immunotherapy, California Pacific Medical Center, San Francisco, California; Apheresis Care Group and Fresenius Medical Care, San Francisco, California.

• PMID: 23893695

• DOI: 10.1002/jca.21286